Pure Hydrocodone Could Make Overdosing Easier Than Ever

​San Diego-based drugmaker Zogenix's resolution for 2012: get the FDA to approve Zohydro, the first pill of pure hydrocodone.

The experimental pain drug, purported to be ten times more powerful than Vicodin, is designed to release its payload of hydrocodone over an extended time. Creative addicts, however, will surely devise ways to circumvent this technology and get a whole lot higher a whole lot faster.

Because the drug is not cut with acetaminophen or other nonaddictive substances, the laws require that patients visit their doctors every time a refill is in order. Although this may curb the likelihood of abuse, some basic number-crunching by Jeffrey Kluger over at Time raises a few red flags:

"It's true too that the new überhydrocodone will require patients to appear at a doctor's office in person each time they want a prescription refilled -- as opposed to simply getting a single prescription with five refills built in, as is sometimes the case with current hydrocodone-based meds. But you're talking about 30 days of hydrocodone pills formulated at 10 times the current dosage. That -- and feel free to check my math here -- is the milligram equivalent of 300 days of the stuff. Might this be a problem?"

It's unclear how the growing scrutiny of pain pills will affect Zogenix's chances of getting the drug approved.

There has been an outcry among addiction experts that such a strong formulation of an already abused drug will lead to an uptick of health issues, overdoses, and associated crimes -- problems South Florida is all too familiar with. Drug Enforcement Agency data show that hydrocodone killed 910 Floridians between 2003 and 2007 and was associated with nearly 2,000 additional deaths in the state.

One potential benefit of a pure hydrocodone pill is that it would eliminate the side effects -- mainly liver failure -- associated with drugs that mix in acetaminophen.

Zogenix said in a December news release that it plans to submit a formal application for the drug in the second quarter of 2012. If the pill passes regulatory muster, pharmacies could start filling scripts come 2013.


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6 comments
Jhn777777
Jhn777777

Nicotine causes cancer. Alcohol causes liver disease. Tylenol causes liver disease. Addicts right now are dying due to the amount of tylenol, ibuprofen, or aspirin in VIcodin. And people like my mom who are in pain every day who do not want anything stronger than Vicodin are dying. Even if you are an addict (forget the zillions of people who have chronic pain like my mother), I do not know if hydrocodone by itself is any worse than smoking cigarettes. I know alcohol is by far worse than just pure hydrocodone consumption on a regular basis.  Alcohol is socially acceptable and ingrained in the culture. People in the bible drink alcohol. 

healthpain
healthpain

Vicodin is a narcotic opioid drug. It is a brand name of the generic drug hydrocodone and acetaminophen. Other brand names available under the same combination drugs are Anexsia, Dolorex Forte, Hycet, Liquicet, Lortab, Lorcet, Xodol, Zydone, Maxidone, Norco, Zamicet, Polygesic, Zolvit etc. Hydrocodone is a narcotic drug often used in combination with acetaminophen or APAP as abbreviated which is a less potent drug that helps in increasing the potency of hydrocodone. It is used for treatment of moderate to severe chronic pain. It works by blocking the pain sensations to the brain and acts on the central nervous system. One can buy Vicodin online or from local area pharmacies.http://www.findrxonline.com/en... 

Billy Binkerton
Billy Binkerton

Can anyone help me with advice?My baby moma and I just brought our baby home from the hospital and since mental illness runs in our family, the doctor recommended getting him started on an anti-depressant and an atypical antipsychotic. The doctor was able to get him to eat the pill easily but now that we got him home, I can't seem to get him to swallow it. It took a video of the doctor giving it to him here: http://www.youtube.com/watch?v... Is there some trick to it? What am I doing wrong?

FQS9000
FQS9000

Giving pure drugs to addicts is a great idea.  It thins out the fools, which is never a bad idea.

Mikoe Wozz
Mikoe Wozz

I am a 27 years old doctor,mature and beautiful. and now i am seeking a good man who can give me real love, so i got a sername Andromeda2002 on  Agedate.СòM, a nice and free place for younger women and older men,or older women and younger men, to interact with each other.Maybe you wanna check out or tell your friends. 

CSMcDonald
CSMcDonald

Headline could also read:"Pure Hydrocodone could mean chronic pain sufferers no longer poisoned with Government's Blessing"

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